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Aldosterone
2D structure for Aldosterone
Chemical Name	11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
Chemical Formula	C21H28O5
CAS Number	52-39-1
Chemical Information	HMDB00037
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Androgen and Estrogen Metabolism Bile Acid Biosynthesis C21-Steroid Hormone Metabolism
Biofluid Location	Blood Saliva Urine
Tissue Location	Adrenal Cortex Adrenal Gland Adrenal Medulla Cardiovascular System Fibroblasts Intestine Kidney Kidneys Lung Muscle Nerves Pancreas Placenta Platelet Skeletal Muscle Testes Testis Thyroid Gland Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.000026 (0.000008 - 0.000044) uM Blood: 0.0004 +/- 0.00004 uM Blood: 0.001 (0.000055 - 0.002) uM Saliva: <1.00 uM Urine: 0.01 (0.006-0.014) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Heart failure
Other (Monogenic Disorders)	Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency OMIM: 202010 Aldosterone deficiency due to defect in 18-hydroxylase OMIM: 203400 Pseudohypoaldosteronism, type II OMIM: 145260
Abnormal Biofluid Concentrations	Blood (Heart failure): 0.0004 +/- 0.00005 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Contents 1 Introduction 2 Biological Function 3 Catabolism 4 Diseases / Conditions Related to Nutrition 5 Other (Monogenic) Disorders 6 Nutritional Information 7 Drivers for biological variation 8 Vulnerable groups 9 Other resources 10 Links

Introduction

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Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidney's collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine.

Biological Function

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Catabolism

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Diseases / Conditions Related to Nutrition

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• Heart failure

Other (Monogenic) Disorders

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• Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency OMIM: 202010
• Aldosterone deficiency due to defect in 18-hydroxylase OMIM: 203400
• Pseudohypoaldosteronism, type II OMIM: 145260

Nutritional Information

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Drivers for biological variation

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Vulnerable groups

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Other resources

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Links

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