Iodotyrosine

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Iodotyrosine
2D structure for Iodotyrosine
Chemical Name	(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
Chemical Formula	C₉H₁₀INO₃
CAS Number	70-78-0
Chemical Information	HMDB00021
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Tyrosine Metabolism
Biofluid Location	Blood
Tissue Location	Thyroid Gland
Normal Biofluid Concentrations	Blood: 0.00069 +/- 0.00020 umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Athyroic patients
Other (Monogenic Disorders)	Thyroid hormonogenesis, genetic defect in, 4 OMIM: 274800
Abnormal Biofluid Concentrations	Blood (Athyroic patients): 0.00032 +/- 0.00008 umol/L
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
An iodated derivative of L-tyrosine. This is an early precursor to L-thyroxine, one of the primary thyroid hormones. In the thyroid gland, iodide is trapped, transported, and concentrated in the follicular lumen for thyroid hormone synthesis. Before trapped iodide can react with tyrosine residues, it must be oxidized by thyroid peroxidase. Iodotyrosine is made from tyrosine via thyroid peroxidase and then further iodinated by this enzyme to make the di-iodo and tri-iodo variants. Two molecules of di-iodotyrosine combine to form T4, and one molecule of mono-iodotyrosine combines with one molecule of di-iodotyrosine to form T3.