Deoxycorticosterone

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Deoxycorticosterone
2D structure for Deoxycorticosterone
Chemical Name	17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Chemical Formula	C₂₁H₃₀O₃
CAS Number	64-85-7
Chemical Information	HMDB00016
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Androgen and Estrogen Metabolism C21-Steroid Hormone Metabolism
Biofluid Location	Amniotic Fluid Blood
Tissue Location	All Tissues
Normal Biofluid Concentrations	Amniotic Fluid: uM Blood: 0.073 (0.034-0.11) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency OMIM: 202010 Aldosterone deficiency due to defect in 18-hydroxylase OMIM: 203400
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

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A steroid or mineralocorticoid secreted by the adrenal cortex. Deoxycorticsterone acts as a precursor to aldosterone. It can be used to treat adrenal insufficiency. In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addison's disease.

Biological Function

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Catabolism

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Diseases / Conditions Related to Nutrition

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Other (Monogenic) Disorders

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Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency OMIM: 202010
Aldosterone deficiency due to defect in 18-hydroxylase OMIM: 203400