Cortexolone

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Cortexolone
2D structure for Cortexolone
Chemical Name	17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Chemical Formula	C₂₁H₃₀O₄
CAS Number	152-58-9
Chemical Information	HMDB00015
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Androgen and Estrogen Metabolism C21-Steroid Hormone Metabolism
Biofluid Location	Blood Urine
Tissue Location	All Tissues
Normal Biofluid Concentrations	Blood: 0.0039 +/- 0.0004 uM Urine: 0.017-178.9 umol/mmol creatinine Urine: 0.02 (0.0091-0.032) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency OMIM: 202010
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Cortexolone is the precursor of cortisol. Accumulation of Cortexolone can happen in a defect known as congenital adrenal hyperplasia, which is due to 11-beta-hydroxylase deficiency, resulting in androgen excess, virilization, and hypertension. (PMID: 2022736) A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities. (PubChem)