From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
| Taxonomy Navigation Box; search by |
|
All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein |
| Glutathione S-Transferase | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for Glutathione S-Transferase]] | |
| Chemical Name | |
| Chemical Formula | |
| CAS Number | |
| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
A family of enzymes that utilize glutathione in reactions contributing to the transformation of a wide range of compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. These enzymes play a key role in the detoxification of such substances.
Biological Function
The glutathione S-transferases (GST) are a family of enzymes responsible for the metabolism of a broad range of xenobiotics and carcinogens.
The cytosolic GSTs are grouped into several classes termed alpha (GSTA), mu (GSTM), kappa (GSTK), theta (GSTT), pi (GSTP), sigma (GSTS), omega (GSTO), zeta (GSTZ) and there is a class of microsomal GSTs (MGST), based on amino acid sequence similarities and antibody cross-reactivities. Each class is encoded by a single gene or a gene family.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation
Vulnerable groups
Other resources
Links