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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| GCSF | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for GCSF]] | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
GCSF is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly and acts in hematopoiesis by controlling the production, differentiation, and function of white cell populations of the blood, the granulocytes and the monocytes-macrophages. This csf induces granulocytes. It is therapeutically available under the names neupogen or granulokine (amgen/roche) and granocyte (rhone-poulenc) and is used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood).
Recommended name:
Granulocyte colony-stimulating factor,GCSF
Alternative name(s):
CSF3
Pluripoietin
INN=Filgrastim
INN=Lenograstim
Biological Function
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.