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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Fibrinogen | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for Fibrinogen]] | |
| Chemical Name | |
| Chemical Formula | |
| CAS Number | |
| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Human fibrinogen
Cleavage of soluble fibrinogen by thrombin to form fibrin is the final common reaction of the coagulation cascade. Low levels of fibrinogen are seen in association with fibrinolysis and liver disease. A high level of fibrinogen is a risk factor for thrombosis and is a strong predictor of cardiovascular risk and stroke, particularly in young adults. Low-dose heparin and ACE-inhibitors reduce fibrinogen and risk of adverse cardiovascular events.
Rodent fibrinogen
Cleavage of soluble fibrinogen by thrombin to form fibrin is the final common reaction of the coagulation cascade. Low levels of fibrinogen are seen in association with fibrinolysis and liver disease. A high level of fibrinogen is a risk factor for thrombosis and is a strong predictor of cardiovascular risk and stroke, particularly in young adults. Low-dose heparin and ACE-inhibitors reduce fibrinogen and the risk of adverse cardiovascular events.
Biological Function
Fibrinogen is a plasma glycoprotein synthesized in the liver, which may have a physiologic role as vasoconstrictors and may aid in local hemostasis during blood clotting. It is composed of 3 structurally different subunits: alpha (FIGA), beta (FIGB), and gamma (FIGG)
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation
Vulnerable groups
Other resources
Links
FIGA
FIGB
FIGG