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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Ferritin | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for Ferritin]] | |
| Chemical Name | |
| Chemical Formula | |
| CAS Number | |
| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Ferritin is found in serum at low concentrations and is directly proportional to the body's iron stores. In general, variations in total body iron stores will be reflected in the serum ferritin level. Serum ferritin levels are very helpful in the evaluation of iron deficiency anemia, anemia of chronic infection, thalassemia, and hemochromatosis. Serum ferritin levels, however, can be nonspecifically elevated in patients with inflammation and or liver disease, regardless of iron stores. This is attributed to hepatocellular leakage of ferritin from damaged cells.
Biological Function
The major funtion of ferritin is the major intracellular iron storage protein in all organisms. Ferritin is an acute-phase protein and its expression is up-regulated in conditions such as uncontrolled cellular proliferation, in any condition marked by excessive production of toxic oxygen radicals, and by infectious and inflammatory processes. Under such conditions ferritin up-regulation is predominantly stimulated by increased reactive oxygen radical production and by cytokines.
Each ferritin molecule comprises 24 subunits. Various combinations of H-subunits and L-subunits make up the 24-subunit protein structure and these ferritin isoforms differ in their H-subunit to L-subunit ratio, as well as in their metabolic properties.
Ferritin light chain
Recommended name:
Ferritin light chain
Ferritin L subunit
Ferritin heavy chain
Recommended name:
Ferritin heavy chain
Ferritin H subunit
EC=1.16.3.1
Alternative name(s):
Cell proliferation-inducing gene 15 protein
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation
Vulnerable groups
Other resources
Links
FTL
FTH