Factor VII

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Factor VII
[[Image:{{{Image}}}\|thumb\|220px\|2D structure for Factor VII]]
Chemical Name
Chemical Formula
CAS Number
Chemical Information
Biochemical Taxonomy
Functional Taxonomy
Nutritional Taxonomy
Metabolic Pathways
Biofluid Location
Tissue Location
Normal Biofluid Concentrations
Normal Tissue Concentrations
Diseases / Conditions Related to Nutrition
Other (Monogenic Disorders)
Abnormal Biofluid Concentrations
Abnormal Tissue Concentrations
Physiological Processes

Authors:	L. Pellis
Affiliations:	TNO, the Netherlands

1 Introduction
2 Biological Function
3 Catabolism
4 Diseases / Conditions Related to Nutrition
- 4.1 Associated decreased protein/metabolite profile
- 4.2 Associated increased protein/metabolite profile
5 Other (Monogenic) Disorders
6 Nutritional Information
7 Drivers for biological variation
8 Vulnerable groups
9 Other resources
10 Links

Introduction

guidelines

Human Factor VII

Factor VII is a trace protein produced in the liver that plays a role in the coagulation cascade. There are two types of Factor VII Deficiency: Inherited Factor VII Deficiency and Acquired Factor VII Deficiency. The inherited type of Factor VII Deficiency is very rare. The disorder itself affects 1 in 1 million people. However, one in approximately 500 people may be a carrier of the defective gene. The acquired form of the disorder happens more often. People can get the acquired form of Factor VII Deficiency if they have severe liver disease which reduces the function of the liver or they have low vitamin K levels as a result of taking certain kinds of medication. In addition, acquired Factor VII deficiency is associated with certain forms of cancer and autoimmune response to Factor VII.

Rodent Factor VII

Factor VII plays a role in the coagulation cascade, the chain reaction that is set in motion when there is an injury to a blood vessel. There are two types of Factor VII Deficiency: Inherited Factor VII Deficiency and Acquired Factor VII Deficiency (which is the result of other physical disorders, and may last only a short time). The inherited type of Factor VII Deficiency affects only 1 in 1 million people. However, one in 500 people may be a carrier of the defective gene. The acquired form of Factor VII Deficiency is more common and can result from severe liver disease which reduces the function of the liver (Factor VII is produced in the liver) or they have low vitamin K levels as a result of taking certain kinds of medication. In addition, acquired Factor VII deficiency is associated with certain forms of cancer and autoimmune response to Factor VII.