From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein |
| FSH | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for FSH]] | |
| Chemical Name | |
| Chemical Formula | |
| CAS Number | |
| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Follicle-stimulating hormone (FSH) is essential for normal reproductive function in males and females. Under physiologic conditions, FSH is secreted into the circulation as a complex mixture of several isoforms that vary in the degree of glycosylation. Glycosylation of FSH is important for the serum half-life of the hormone and coupling of the receptor to adenylate cyclase.
Biological Function
Stimulates development of follicle and spermatogenesis in the reproductive organs.
In humans, a single gene encodes a common alpha chain of 4 glycoprotein hormones: chorionic gonadotropin, follicle-stimulating hormone, luteinizing hormone, and thyroid-stimulating hormone (FSHA). The hormone-specific beta chains of these related hormones are encoded by separate genes. The FSHB gene encodes the beta subunit of follicle-stimulating hormone.
FSHA
Recommended name:
Glycoprotein hormones alpha chain, GLHA
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follitropin alpha chain
Follicle-stimulating hormone alpha chain, FSH-alpha, FSHA
Lutropin alpha chain
Luteinizing hormone alpha chain, LSH-alpha, LSHA
Thyrotropin alpha chain
Thyroid-stimulating hormone alpha chain, TSH-alpha, TSHA
Choriogonadotropin alpha chain
Chorionic gonadotrophin alpha subunit, CG-alpha, CGA
FSHB
Recommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit, FSH-beta, FSH-B
Follitropin beta chain
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation
Vulnerable groups
Other resources
Links
guidelines
FSHA
FSHB