From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| FGF-basic | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for FGF-basic]] | |
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| Diseases / Conditions Related to Nutrition | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
FGF-basic is a heparin binding growth factor which stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. It is a potent mitogen for arterial smooth muscle cells, plays a pivotal role in the pathogenesis of arteriosclerosis and restenosis. Human FGF-basic also exerts a potent angiogenic activity in vivo.
Recommended name:
Heparin-binding growth factor 2, HBGF-2
Alternative name(s):
Basic fibroblast growth factor, BFGF
Biological Function
The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.