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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Eotaxin | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for Eotaxin]] | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Chemoattractant cytokines (chemokines) play an important role in the recruitment of leukocytes to inflammatory lesions. Eotaxin is produced by epithelial cells, endothelial cells, and eosinophils, and its expression is enhanced in allergic inflammation. Thus, eotaxin is thought to play an important role in allergy and asthma. The positions of four cysteine residues in eotaxin place it in the C-C family of chemokines, along with chemokines such as RANTES, MCP-3, and MIP-1 alpha.
Biological Function
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.