From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Endothelin-1 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for Endothelin-1]] | |
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| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
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| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Endothelins are the most potent vasoconstrictors known. In addition to their vasoconstrictor actions, endothelins have effects on the central nervous system and on neuronal excitability. They induce the depolarization of spinal neurons, the release of vasopressin and oxytocin, and may be involved in the response of glial cells to tissue injuries. Elevated plasma concentrations of endothelins have been observed in hypertension, myocardial infarction, cardiogenic shock, Raynaud syndrome, and Crohn's disease.
Biological Function
Endothelins are endothelium-derived vasoconstrictor peptides.