From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| ENRAGE | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for ENRAGE]] | |
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| Nutritional Taxonomy | |
| Metabolic Pathways | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
The protein encoded by this gene is a member of the S100 family of proteins. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. ENRAGE is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. Interaction of ENRAGE with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. In murine models, blockade of ENRAGE/RAGE quenched delayed-type hypersensitivity and inflammatory colitis by arresting activation of central signaling pathways and expression of inflammatory gene mediators.
Biological Function
ENRAGE is expressed in neutrophils, and are abundant in infiltrating monocytes and granulocytes under conditions of chronic inflammation.
Recommended name:
Protein S100-A12
Alternative name(s):
EXTRACELLULAR NEWLY IDENTIFIED RAGE-BINDING PROTEIN, ENRAGE
S100 calcium-binding protein A12
Calgranulin-C, CAGC
Calgranulin related protein, CGRP
Neutrophil S100 protein
Calcium-binding protein in amniotic fluid 1, CAAF1
p6
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation