D-Xylulose

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D-Xylulose
2D structure for D-Xylulose
Chemical Name	D-threo-pent-2-ulose
Chemical Formula	C₅H₁₀O₅
CAS Number	551-84-8
Chemical Information	HMDB01644
Biochemical Taxonomy	Not Available
Functional Taxonomy	Not Available
Nutritional Taxonomy	Carbohydrates
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Fibroblasts
Normal Biofluid Concentrations	Blood: 0.0 - 5.0 uM Cerebrospinal Fluid (CSF): 0.0 - 5.0 uM Urine: 0.0 - 5.0 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Ribose-5-Phosphate Isomerase Deficiency
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Ribose-5-Phosphate Isomerase Deficiency): 5.0 - 10.0 uM Cerebrospinal Fluid (CSF) (Ribose-5-Phosphate Isomerase Deficiency): 88 - 166 uM Urine (Ribose-5-Phosphate Isomerase Deficiency): 39 - 52 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
D-xylulose is a monosaccharide containing five carbon atoms. D-xylulose is converted from xylitol by the enzyme NAD+-linked xylitol dehydrogenase (EC 1.1.1.9) in the glucuronate pathway, the most important xylitol-handling metabolic pathway in mammals. This activity has been described in human erythrocytes. Most likely, D-Xylulose (as well as D-arabinose or D-ribulose) is a precursor of the pentiol D-arabitol, since pentitols are derived from their corresponding pentose phosphate precursors via pentoses. This pathway can play a role in inherited metabolic disorders underlying the accumulation of pentitols e.g., ribose 5-phosphate isomerase deficiency and transaldolase deficiency. Although pentitols are present in all living organisms, knowledge concerning their metabolism is limited. (PMID: 15234337, Mol Genet Metab. 2004 Jul;82(3):231-7.)