D-Threitol

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D-Threitol
2D structure for D-Threitol
Chemical Name	(2R,3R)-butane-1,2,3,4-tetrol
Chemical Formula	C₄H₁₀O₄
CAS Number	2418-52-2
Chemical Information	HMDB04136
Biochemical Taxonomy	Not Available
Functional Taxonomy	Not Available
Nutritional Taxonomy	Carbohydrates
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.0 - 5.0 uM Cerebrospinal Fluid (CSF): 0.0 - 7.0 uM Urine: 7.0 - 83 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Ribose-5-Phosphate Isomerase Deficiency
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Ribose-5-Phosphate Isomerase Deficiency): 5.0 - 8.0 uM Cerebrospinal Fluid (CSF) (Ribose-5-Phosphate Isomerase Deficiency): 29 - 67 uM Urine (Ribose-5-Phosphate Isomerase Deficiency): 38 - 81 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
D-Threitol can be regarded as the main end product of D-xylose metabolism in man. Threitol is a C4-polyol (tetritol); the total C4-polyol concentration of threitol decreases with age. Several inborn errors of metabolism with abnormal polyol concentrations in body fluids are known to date (such as pentosuria and galactosemia). Most of these defects can be diagnosed by the assessment of urinary concentrations of polyols. Several studies have revealed that urinary levels of some polyols may vary in diseases associated with carbohydrate metabolism derangements such as diabetes mellitus and uremia. The abnormal occurrence of various polyols in diseases with a specific enzyme deficiency such as pentosuria4 and galactosemias has also been reported. (PMID: 908147, 16435188, 14988808, Analytical Sciences (1990), 6(5), 657-66.)