D-Mannose

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D-Mannose
2D structure for D-Mannose
Chemical Name	(3S,4S,5R,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
Chemical Formula	C₆H₁₂O₆
CAS Number	3458-28-4
Chemical Information	HMDB00169
Biochemical Taxonomy	Not Available
Functional Taxonomy	Not Available
Nutritional Taxonomy	Carbohydrates
Metabolic Pathways	Aminosugars Metabolism Fructose and Mannose Metabolism Galactose Metabolism Glycerolipid Metabolism Glycolysis Glycosphingolipid Metabolism N-glycan Biosynthesis Starch and Sucrose Metabolism Streptomycin Biosynthesis
Biofluid Location	Blood Breast Milk Cerebrospinal Fluid (CSF)
Tissue Location	Bladder Epidermis Fibroblasts Intestine Kidney Muscle Myelin Pancreas Placenta Spleen Testes Testis Adrenal Medulla
Normal Biofluid Concentrations	Blood: 39.0 +/- 7.0 uM Blood: 64.0 +/- 12.0 uM Breast Milk: 66.4 +/- 2.3 uM Cerebrospinal Fluid (CSF): 24 +/- 13 uM Cerebrospinal Fluid (CSF): 64.0 (56.0-72.0) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Congenital disorder of glycosylation, type IA OMIM: 212065 Congenital disorder of glycosylation, type IB OMIM: 602579
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
D-Mannose is a carbohydrate. High-mannose-type oligosaccharides have been shown to play important roles in protein quality control. Several intracellular proteins, such as lectins, chaperones and glycan-processing enzymes, are involved in this process. These include calnexin/calreticulin, UDP-glucose:glycoprotein glucosyltransferase (UGGT), cargo receptors (such as VIP36 and ERGIC-53), mannosidase-like proteins (e.g. EDEM and Htm1p) and ubiquitin ligase (Fbs). They are thought to recognize high-mannose-type glycans with subtly different structures. Mannose-binding lectin (MBL) is an important constituent of the innate immune system. This protein binds through multiple lectin domains to the repeating sugar arrays that decorate many microbial surfaces, and is then able to activate the complement system through a specific protease called MBL-associated protease-2. The primary pathway for the formation of L-fucose in procaryotic and eucaryotic cells is from D-mannose via an internal oxidation reduction and then epimerization of GDP-D-mannose to produce GDP-L-fucose. (PMID: 9488699, 16154739, 11414367)