Creatinine

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Creatinine
2D structure for Creatinine
Chemical Name	2-amino-1,5-dihydro-1-methyl-4H-Imidazol-4-one
Chemical Formula	C₄H₇N₃O
CAS Number	60-27-5
Chemical Information	HMDB00562
Biochemical Taxonomy	Amino Ketones
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Saliva Urine
Tissue Location	Bladder Fibroblasts Kidney Kidneys Liver Muscle Nerves Pancreas Placenta Platelet Prostate Skeletal Muscle Spleen Testis Thyroid Gland Adipose Tissue
Normal Biofluid Concentrations	Blood: 60.0 (50.0 - 80.0) uM Blood: 72.0 (57.0 - 93.0) uM Blood: 73.5 +/- 15.0 uM Cerebrospinal Fluid (CSF): 43 +/- 12 uM Cerebrospinal Fluid (CSF): 64.95 (37.5-92.4) uM Cerebrospinal Fluid (CSF): 65.2 (51.8-78.6) uM Saliva: >10 uM Urine: 1046.0 +/- 204.0 umol/mmol creatinine Urine: 230.0 (98.0-1052.0) umol/mmol creatinine Urine: 677.0 +/- 46.0 umol/mmol creatinine Urine: 697.0 (349.0-1050.0) umol/mmol creatinine Urine: 931.0 (467.0-1390.0) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Hemodialysis (after a 4 hour dialysis session) Hemodialysis (before a 4 hour dialysis session) Paraquat poisoning Patients with Canavan disease
Other (Monogenic Disorders)	Hypocalciuric hypercalcemia, familial, type I OMIM: 145980 Mucopolysaccharidosis type VI OMIM: 253200
Abnormal Biofluid Concentrations	Blood (Hemodialysis (after a 4 hour dialysis session)): 40.3 +/- 14.5 uM Blood (Hemodialysis (before a 4 hour dialysis session)): 102.5 +/- 30.1 uM Blood (Patients with Canavan disease): 35.23 +/- 5.28 umol/L Urine (Paraquat poisoning): 148.0 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. Creatinine is transferred to the kidneys by blood plasma, whereupon it is eliminated from the body by glomerular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate by the body. Measuring serum creatinine is a simple test and it is the most commonly used indicator of renal function. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. The typical reference range for women is considered about 45-90 umol/l, for men 60-110 umol/l. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.