Corticosterone

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Corticosterone
2D structure for Corticosterone
Chemical Name	(8R,9S,10S,11R,13S,14R,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Chemical Formula	C₂₁H₃₀O₄
CAS Number	50-22-6
Chemical Information	HMDB01547
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Androgen and Estrogen Metabolism Bile Acid Biosynthesis C21-Steroid Hormone Metabolism
Biofluid Location	Blood
Tissue Location	Adrenal Cortex Adrenal Gland Brain Epidermis Fibroblasts Gonads Hypothalamus Intestine Kidney Liver Nerves Neurons Placenta Platelet Spleen Stratum Corneum Testes Testis Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.027 +/- 0.005 umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Patients with depersonalization syndrome
Other (Monogenic Disorders)	Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency OMIM: 202010 Aldosterone deficiency due to defect in 18-hydroxylase OMIM: 203400
Abnormal Biofluid Concentrations	Blood (Patients with depersonalization syndrome): 0.023 +/- 0.0034 umol/L
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

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An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Biological Function

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Catabolism

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Diseases / Conditions Related to Nutrition

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Patients with depersonalization syndrome

Other (Monogenic) Disorders

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Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency OMIM: 202010
Aldosterone deficiency due to defect in 18-hydroxylase OMIM: 203400