Ceramide (d18:1/9Z-18:1)

From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

Ceramide (d18:1/9Z-18:1)
2D structure for Ceramide (d18:1/9Z-18:1)
Chemical Name	(Z)-N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)octadec-9-enamide
Chemical Formula	C₃₆H₆₉NO₃
CAS Number	104404-17-3
Chemical Information	HMDB04948
Biochemical Taxonomy	Not Available
Functional Taxonomy	Second Messenger
Nutritional Taxonomy	Lipids
Metabolic Pathways	Galactose Metabolism Glycerolipid Metabolism Glycerophospholipid Metabolism Glycosphingolipid Metabolism
Biofluid Location	Blood
Tissue Location	Epidermis Fibroblasts Intestine Keratinocyte Kidney Liver Muscle Myelin Nerves Neuron Neurons Pancreas Placenta Platelet Skeletal Muscle Skin Spleen Stratum Corneum Testes Thyroid Gland Brain
Normal Biofluid Concentrations	Blood: 9.0 +/- 2.3 umol/L
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Patients with Fabry disease
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Patients with Fabry disease): 7.22 (6.4-42.5) umol/L
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935) and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID 14998372). Is key in the biosynthesis of glycosphingolipids and gangliosides.