From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein |
| Cancer Antigen 125 | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for Cancer Antigen 125]] | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Cancer antigen 125 (CA 125) is a glycoprotein found in increased amounts on the cell surface of many ovarian epithelial malignancies. Elevated levels of CA 125 are associated with serous, endometrioid, and clear cell carcinomas of the ovary. More than 80 percent of non-mucinous, epithelial ovarian carcinomas have elevated levels of CA 125. Conditions such as endometriosis, normal pregnancy, pelvic inflammatory disease, uterine fibroids, hepatitis, pancreatitis, and cirrhosis may contribute to elevated levels of serum CA 125. Malignancies of breast, lung, and gastrointestinal tract may also be associated with an elevation of this tumor marker