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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Calcitonin | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for Calcitonin]] | |
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| Biochemical Taxonomy | |
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| Nutritional Taxonomy | |
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| Biofluid Location | |
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| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
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| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Calcitonin is secreted by the parafollicular C-cells of the thyroid gland. Its primary physiological effect is to lower serum calcium levels. Elevated levels of calcitonin (>100 pg/mL) may be encountered in a variety of pathological conditions including leukemias and myeloproliferative disorders. The most notable condition expressing elevated calcitonin levels is medullary thyroid carcinoma (MTC).
Biological Function
Calcitonin is a peptide hormone synthesized by the parafollicular cells of the thyroid. It causes reduction in serum calcium, an effect opposite to that of parathyroid hormone.