From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Brain-Derived Neurotrophic Factor | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for Brain-Derived Neurotrophic Factor]] | |
| Chemical Name | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Brain-Derived Neurotrophic Factor (BDNF) is a protein found in the neurons of the nervous system where it helps to support the survival of existing neurons, and encourage the growth of new neurons and synapses. Various studies have shown possible links between low levels of BDNF and conditions such as depression, obsessive-compulsive disorder, Alzheimer's disease or senile dementia of Alzheimer's type which is a disorder or loss of mental functions resulting from brain tissue changes.
Biological Function
Brain-derived neurotrophic factor is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation