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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Betacellulin | |
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| [[Image:{{{Image}}}|thumb|220px|2D structure for Betacellulin]] | |
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| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
The mammalian members of the epidermal growth factor (EGF) family of growth factors include EGF itself, transforming growth factor-alpha (TGFA), amphiregulin (AREG), heregulin (HGL), and betacellulin (BTC). These molecules all are synthesized primarily as transmembrane precursors, and the precursors are processed to mature molecules by proteolytic events. BTC is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. BTC binds and activates ErbB-1 and ErbB-4 homodimers and is further characterised by its unique ability to activate all possible heterodimeric ErbB receptors. BTC is widely expressed in most tissues and various body fluids, including milk. Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells.
Biological Function
Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family.