Apolipoprotein A1

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Apolipoprotein A1
[[Image:{{{Image}}}\|thumb\|220px\|2D structure for Apolipoprotein A1]]
Chemical Name
Chemical Formula
CAS Number
Chemical Information
Biochemical Taxonomy
Functional Taxonomy
Nutritional Taxonomy
Metabolic Pathways
Biofluid Location
Tissue Location
Normal Biofluid Concentrations	1.0-1.5 mg/ml
Normal Tissue Concentrations
Diseases / Conditions Related to Nutrition
Other (Monogenic Disorders)
Abnormal Biofluid Concentrations
Abnormal Tissue Concentrations
Physiological Processes

Authors:	L. Pellis
Affiliations:	TNO, the Netherlands

1 Introduction
2 Biological Function
3 Catabolism
4 Diseases / Conditions Related to Nutrition
- 4.1 Associated decreased protein/metabolite profile
- 4.2 Associated increased protein/metabolite profile
5 Other (Monogenic) Disorders
6 Nutritional Information
7 Drivers for biological variation
8 Vulnerable groups
9 Other resources
10 Links

Introduction

guidelines

Human Apolipoprotein A1

Apo A1 is primarily found in high density lipoprotein (HDL) particles. It serves to prevent the accumulation of cholesterol loaded macrophages which deposit on the arterial wall as foam cells. Its primary function is to activate LCAT within the HDL complex, which catalyzes the esterification of cholesterol. This results in a more soluble cholesterol-HDL complex which increases the cholesterol transport capacity of the HDL particle for subsequent removal by the liver. Apo AI is therefore a convenient marker for assessing the cholesterol clearing capacity of the blood, and studies have clearly indicated that it is a better discriminator of angiographically documented coronary artery disease than HDL cholesterol.

Rodent Apolipoprotein A1

Apo A1 is primarily found in high density lipoprotein (HDL) particles. It serves to prevent the accumulation of cholesterol loaded macrophages which deposit on the arterial wall as foam cells. This is the prominent early feature of atherosclerotic lesion formation ultimately resulting in atherosclerosis. Its primary function is to activate LCAT within the HDL complex, which catalyzes the esterification of cholesterol. This results in a more soluble cholesterol-HDL complex which increases the cholesterol transport capacity of the HDL particle for subsequent removal by the liver. Apo AI is therefore a convenient marker for assessing the cholesterol clearing capacity of the blood, and studies have clearly indicated that it is a better discriminator of angiographically documented coronary artery disease than HDL cholesterol.