Androsterone glucuronide

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Androsterone glucuronide
2D structure for Androsterone glucuronide
Chemical Name	(2S,3S,4S,5R,6R)-6-[[(3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxy-oxane-2-carboxylic acid
Chemical Formula	C₂₅H₃₈O₈
CAS Number	1852-43-3
Chemical Information	HMDB02829
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood
Tissue Location	Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.001 - 0.003 uM Blood: 0.03 +/- 0.0064 uM Blood: 0.046 - 0.054 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	After a single oral 120-mg dose of testosterone (doping)
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (After a single oral 120-mg dose of testosterone (doping)): 0.25 - 1.33 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Androsterone glucuronide (ADT-G) is one of the major circulating C19-steroid metabolites in humans. Human and monkey are unique in having high levels of circulating ADT-G. Furthermore, the plasma levels of these glucuronide derivatives reflect the peripheral tissue conversion of adrenal and gonadal precursor C19-steroids to active androgens in various pathophysiological conditions. Identification and characterization of human UDP-glucuronosyltransferase 2B (UGT2Bs) demonstrated the major role that these enzymes play in androgen conjugation, with UGT2B15 and UGT2B17 (EC 2.4.1.17) being the major androsterone-conjugating isoforms. Exaggerated androsterone metabolism, is observed in hyper-androgenic as well as in some normo-androgenic women with acne and androsterone glucuronide could be a marker in differentiating acne and hirsutism in hyperandrogenic women. Present data shows that the most practical and probably only valid means of assessing androgenic activity in women is to measure ADT-G, the metabolite that accounts for 93% of the total androgen glucuronide derivatives. (PMID: 12943709, 12445184, 16621522)