From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| Amphiregulin | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for Amphiregulin]] | |
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| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Amphiregulin (AREG) is a member of the epidermal growth factor receptor (EGFR) family of ligands that binds exclusively to EGFR (ErbB1). Unlike the other EGFR ligands, AREG is upregulated in the mammary gland during ductal elongation, rendering this growth factor a likely mediator of epithelial proliferation. Furthermore, ductal outgrowth is severely impaired in AREG-/- mice, similar to the phenotype displayed by ERĪ±-null mammary glands.
Biological Function
Amphiregulin is a heparin-binding, heparin-inhibited member of the epidermal growth factor family and an autocrine growth factor for human keratinocytes.