From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
| Taxonomy Navigation Box; search by |
|
All Metabolites | Biochemical | Nutritional | Functional | Metabolic Pathways | Diseases | Phenotypes | Physiological Processes | Protein |
| Alpha-1 Antitrypsin | |
|---|---|
| [[Image:{{{Image}}}|thumb|220px|2D structure for Alpha-1 Antitrypsin]] | |
| Chemical Name | |
| Chemical Formula | |
| CAS Number | |
| Chemical Information | |
| Biochemical Taxonomy | |
| Functional Taxonomy | |
| Nutritional Taxonomy | |
| Metabolic Pathways | |
| Biofluid Location | |
| Tissue Location | |
| Normal Biofluid Concentrations | |
| Normal Tissue Concentrations | |
| Diseases / Conditions Related to Nutrition | |
| Other (Monogenic Disorders) | |
| Abnormal Biofluid Concentrations | |
| Abnormal Tissue Concentrations | |
| Physiological Processes | |
| Authors: | L. Pellis |
| Affiliations: | TNO, the Netherlands |
Contents |
Introduction
Alpha-1 antitrypsin is a liver protein that blocks the destructive effects of certain enzymes. Alpha-1 antitrypsin deficiency results from a genetic defect. The mechanism that causes associated liver disease and emphysema in some people with this deficiency is not known. However some evidence suggests that it may be related to inflammation. Approximately 75% of adults with severe deficiency will develop emphysema, which often begins before 40 years of age. Smoking can increase risk.
Biological Function
Alpha-1-antitrypsin is a protease inhibitor.
Catabolism
Diseases / Conditions Related to Nutrition
Associated decreased protein/metabolite profile
Associated increased protein/metabolite profile
Other (Monogenic) Disorders
Nutritional Information
Drivers for biological variation