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Acetaminophen
2D structure for Acetaminophen
Chemical Name	N-(4-hydroxyphenyl)acetamide
Chemical Formula	C8H9NO2
CAS Number	103-90-2
Chemical Information	HMDB01859
Biochemical Taxonomy	Misc
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Cerebrospinal Fluid (CSF)
Tissue Location	All Tissues
Normal Biofluid Concentrations	Cerebrospinal Fluid (CSF): 11 +/- 6 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Contents 1 Introduction 2 Biological Function 3 Catabolism 4 Diseases / Conditions Related to Nutrition 5 Other (Monogenic) Disorders 6 Nutritional Information 7 Drivers for biological variation 8 Vulnerable groups 9 Other resources 10 Links

Introduction

Guidelines |guidelines]
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported after therapeutic doses, but critical analysis indicates that most patients with alleged toxicity from therapeutic doses have taken overdoses. Importantly, prospective studies indicate that therapeutic doses of paracetamol are an unlikely cause of hepatotoxicity in patients who ingest moderate to large amounts of alcohol. (PMID 15733027) Single doses of paracetamol are effective analgesics for acute postoperative pain and give rise to few adverse effects. (PMID 14974073) Acetaminophen (AAP) overdose and the resulting hepatotoxicity is an important clinical problem. In addition, AAP is widely used as a prototype hepatotoxin to study mechanisms of chemical-induced cell injury and to test the hepatoprotective potential of new drugs and herbal medicines. Because of its importance, the mechanisms of AAP-induced liver cell injury have been extensively investigated and controversially discussed for many years. (PMID 16863451)

Biological Function

Function Guidelines |guidelines]

Catabolism

Related Guidelines |guidelines]

Diseases / Conditions Related to Nutrition

Related Diseases Guidelines |guidelines]

Other (Monogenic) Disorders

Diseases Guidelines |guidelines]

Nutritional Information

Information Guidelines |guidelines]

Drivers for biological variation

for biological variation Guidelines |guidelines]

Vulnerable groups

groups Guidelines |guidelines]

Other resources

resources Guidelines |guidelines]

Links

Guidelines |guidelines]