8-Isoprostane

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8-Isoprostane
2D structure for 8-Isoprostane
Chemical Name	1R-Heptyl-2S-octyl-cyclopentane
Chemical Formula	C₂₀H₄₀
CAS Number	155976-51-5
Chemical Information	HMDB04659
Biochemical Taxonomy	Prostanoids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Platelet Skin Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.00014 +/- 0.00005 uM Blood: 0.00047 +/- 0.000014 umol/L Blood: 0.00053 +/- 0.000043 umol/L Cerebrospinal Fluid (CSF): 0.000021 (0.0000071-0.000035) uM Cerebrospinal Fluid (CSF): 0.00003 +/- 0.00002 uM Urine: 0.00007 - 0.0005 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Pediatric traumatic brain injury Traumatic Brain Injury
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Pediatric traumatic brain injury): 0.00026 (0.00017-0.00035) uM Cerebrospinal Fluid (CSF) (Traumatic Brain Injury): 0.0003 +/- 0.0001 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
8-isoprostane concentrations are elevated in asthma and increase with the clinical severity and during acute asthma episodes. Isoprostane is formed in the airways of asthmatic patients from peroxidation of poly-unsaturated fatty acids in cell membranes, the effect of reactive oxygen species resulting of the NADPH oxidase of eosinophils, neutrophils and alveolar macrophages, which produces superoxide anion which undergoes dismutation to H2O2. (PMID 16354413) 8-isoprostane is also elevated in Bronchopulmonary dysplasia, which remains an important cause of morbidity and mortality in extremely premature newborn infants receiving intensive care and is the most common contributing factor to severe respiratory morbidity and mortality in early childhood. (PMID 14980283) 8-Isoprostaglandin F(2a) is a marker of oxidative stress in the aqueous humour of patients with exfoliation syndrome (XFS) (PubMed ID 12598453)