8-Hydroxyguanosine

From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

8-Hydroxyguanosine
2D structure for 8-Hydroxyguanosine
Chemical Name	2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
Chemical Formula	C₁₀H₁₃N₅O₆
CAS Number	3868-31-3
Chemical Information	HMDB02044
Biochemical Taxonomy	Nucleosides
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.00000000142 +/- 0.00000000059 +/- 0.0 uM Cerebrospinal Fluid (CSF): 0.0001 +/- 0.00003 (0.00004 - 0.00014) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Alzheimer's Disease Parkinson's Disease Parkinson's disease
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Alzheimer's Disease): 0.00000000153 +/- 0.00000000060 uM Blood (Parkinson's Disease): 0.00000000149 +/- 0.00000000054 uM Cerebrospinal Fluid (CSF) (Parkinson's disease): 0.0003 +/- 0.00013 (0.00015 - 0.0004) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
8-hydroxyguanosine (8-OHG) is a marker for measuring the rate of oxidative damage to nucleic acids and lipids. Production of reactive oxygen species (ROS) damage proteins, lipid membranes, and nucleic acids (DNA and RNA), all critical functional components of living cells. The progressive accumulation of unrepaired free radical damage over time is believed to be a major contributor to the aging process and to a variety of age-related chronic diseases. Generation of most free radicals is a 'side effect' of normal metabolic processes, especially mitochondrial production of ROS, including superoxide anion, hydrogen peroxide, and hydroxyl radical, coincident to oxidative metabolism. (PMID 14607529) 8-OHG (marker of oxidative damage to RNA) was found in the cerebral cortex in three of six cases of neuropathologically examined autopsy of subacute sclerosing panencephalitis patients. Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated measles virus, showing inflammation, neuronal loss, and demyelination. (PMID 12546425) The concentration of 8-OHG in CSF in Parkinson's disease (PD) patients is approximately three-fold that in controls. The concentration of 8-OHG in CSF decreased significantly with the duration of disease. However, the concentration of 8-OHG in serum was not significantly altered in PD patients compared to that in controls. (PMID 12499051)