8-Hydroxyguanine

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8-Hydroxyguanine
2D structure for 8-Hydroxyguanine
Chemical Name	2-amino-7,9-dihydro-3H-purine-6,8-dione
Chemical Formula	C₅H₅N₅O₂
CAS Number	5614-64-2
Chemical Information	HMDB02032
Biochemical Taxonomy	Purines and Purine Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.0001 +/- 0.00015 umol/L Cerebrospinal Fluid (CSF): 0.68 (0.49-0.87) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Alzheimer's disease Diabetic patients
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Diabetic patients): 0.005 +/- 0.0007 umol/L Cerebrospinal Fluid (CSF) (Alzheimer's disease): 0.19 (0.15-0.23) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
Formation of 8-hydroxyguanine (8-OHG), a mutagenic base which is a marker for OH-mediated DNA damage, requires peroxidase and halides and occurs in the presence of transition metal chelators (DTPA +/- desferrioxamine), and is inhibited by catalase, superoxide dismutase (SOD), and scavengers of hypohalous acids. (PMID 10820020) 8-Hydroxyguanine is an oxidative stress marker for diagnosis of Alzheimer's disease (AD). (PMID 15977989)