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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| 8-HETE | |
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| Chemical Name | (5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid |
| Chemical Formula | C20H32O3 |
| CAS Number | 70968-93-3 |
| Chemical Information | HMDB05080 |
| Biochemical Taxonomy |
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| Functional Taxonomy | Not Available |
| Nutritional Taxonomy | Not Available |
| Metabolic Pathways | Not Available |
| Biofluid Location | Not Available |
| Tissue Location | Not Available |
| Normal Biofluid Concentrations | Not Available |
| Normal Tissue Concentrations | Not Available |
| Diseases / Conditions Related to Nutrition | Not Available |
| Other (Monogenic Disorders) | Not Available |
| Abnormal Biofluid Concentrations | Not Available |
| Abnormal Tissue Concentrations | Not Available |
| Physiological Processes | Not Available |
| Authors: | |
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Contents |
Introduction
guidelines
8-HETE is a lipoxygenase-catalyzed metabolite of arachidonic acid. Lipoxygenase (LO) and cytochrome P450 monooxygenase products of arachidonic acid (AA) have been implicated in a large number of vasoregulatory processes. ex-vivo-perfused human lungs release 8-HETE into the vascular compartment in response to inflammatory challenge. 8-HETE is fatty acid metabolite known to activate the PPAR receptors. In the rat, 8-HETE is the key metabolite of arachidonic acid that regulates corneal epithelial cell migration during wound healing. (PMID: 10956057, 10852767, 10832716, 16137885)
Biological Function
Catabolism
Diseases / Conditions Related to Nutrition
Other (Monogenic) Disorders