7b-Hydroxycholesterol

From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

7b-Hydroxycholesterol
2D structure for 7b-Hydroxycholesterol
Chemical Name	(3S,7R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
Chemical Formula	C₂₇H₄₆O₂
CAS Number	566-27-8
Chemical Information	HMDB06119
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.011 +/- 0.0027 umol/L Cerebrospinal Fluid (CSF): 0.003 +/- 0.0006 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Multiple Sclerosis
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Multiple Sclerosis): 0.004 +/- 0.0017 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
7b-Hydroxycholesterol is identified in atheromatous plaques and in plasma of atherosclerotic patients.(PMID: 16604541)

7b-Hydroxycholesterol induces apoptosis in Caco-2 cells and alters Lysosomal membrane integrity. It exhibites a specific enhancement of oxidative stress and of endonuclease G expression. (PMID: 17136497)