6-keto-Prostaglandin F1a

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6-keto-Prostaglandin F1a
2D structure for 6-keto-Prostaglandin F1a
Chemical Name	7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]-6-oxoheptanoic acid
Chemical Formula	C₂₀H₃₄O₆
CAS Number	58962-34-8
Chemical Information	HMDB02886
Biochemical Taxonomy	Prostanoids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Urine
Tissue Location	Placenta Platelet Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.000081 (0.0-0.00016) umol/L Urine: 0.00000026 (0.00000021-0.00000032) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Resuscitated patients Rheumatoid arthritis
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Resuscitated patients): 0.00074 +/- 0.00017 umol/L Urine (Rheumatoid arthritis): 0.00000035 (0.00000033-0.00000037) umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
6-keto-Prostaglandin F1a is the physiologically active and stable metabolite of prostacyclin. (A prostaglandin found in nearly all mammalian tissue that is a powerful vasodilator and inhibits platelet aggregation; it is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue; the sodium salt has been also used to treat primary pulmonary hypertension (Hypertension, Pulmonary). A delayed and prolonged increase in 6-keto-PGF1 alpha is reported in animals with septic shock, i.e., those with fecal peritonitis or cecal ligation. 6-keto-Prostaglandin F1a plasma levels has been found increased in patients with epidemic hemorrhagic fever, in patients with acute obstructive suppurative cholangitis, in patients with gynecologic cancer and has significant correlation with the level of high density lipoprotein cholesterol in plasma. (PMID 1976492, 2298410, 2379443, 2111556)