5-Thymidylic acid

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5-Thymidylic acid
2D structure for 5-Thymidylic acid
Chemical Name [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxyphosphonic acid
Chemical Formula C10H15N2O8P
CAS Number 365-07-1
Chemical Information HMDB01227
Biochemical Taxonomy

  • Nucleotides

Functional Taxonomy

  • DNA Component

Nutritional Taxonomy Not Available
Metabolic Pathways

  • Nicotinate and Nicotinamide Metabolism
  • One Carbon Pool by Folate
  • Purine Metabolism

Biofluid Location

  • Blood

Tissue Location

  • Fibroblasts

Normal Biofluid Concentrations

  • Blood: 1.4 +/- 0.5 uM

Normal Tissue Concentrations Not Available
Diseases / Conditions Related to Nutrition Not Available
Other (Monogenic Disorders) Not Available
Abnormal Biofluid Concentrations Not Available
Abnormal Tissue Concentrations Not Available
Physiological Processes Not Available
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Contents

Introduction

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5-Thymidylic acid is a thymine nucleotide. Also known as thymidine monophosphate, and abbreviated TMP, is a nucleotide that is found in DNA. It is an ester of phosphoric acid with the nucleoside thymidine. TMP consists of a phosphate group, esterified to the the pentose sugar deoxyribose moiety, and the nucleobase thymine. In mammalian cells, thymidine deprivation induces chromosome aberrations such as chromatid breaks, chromatid interchanges, and chromosome fragmentation. (PMID 3888175)


Biological Function

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Catabolism

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Diseases / Conditions Related to Nutrition

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Other (Monogenic) Disorders

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Nutritional Information

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Drivers for biological variation

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Vulnerable groups

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Other resources

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Links

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