5-Methoxydimethyltryptamine

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5-Methoxydimethyltryptamine
2D structure for 5-Methoxydimethyltryptamine
Chemical Name	2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine
Chemical Formula	C₁₃H₁₈N₂O
CAS Number	1019-45-0
Chemical Information	HMDB02004
Biochemical Taxonomy	Cyclic Amines
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.21 +/- 0.03 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Acute paranoid schizophrenia
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Acute paranoid schizophrenia): uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
5-Methoxydimethyltryptamine, like all Methoxydimethyltryptamines is a compound that contain the biogenic monoamine tryptamine and is substituted with one methoxy group and two methyl groups. Members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains. They are possibly involved in the etiology of schizophrenia. (PubChem) They are formed as metabolites of serotonin (5-hydroxytryptamine) or tryptamine by the enzyme indolethylamine N-methyltransferase (INMT). The physiological significance of the N-methylating pathway of indoleamine metabolism, and of the methylated end products, is unknown. Because of the known psychotropic properties of the dimethylated amines, their possible involvement in the chemical pathogenesis of mental disorders has received wide interest. The hallucinogenic actions of the methylated indoleamines, like those of LSD, are believed to be mediated through the 5HT2 receptor. (PMID 11763413)