5-Hydroxytryptophol

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5-Hydroxytryptophol
2D structure for 5-Hydroxytryptophol
Chemical Name	3-(2-hydroxyethyl)-1H-indol-5-ol
Chemical Formula	C₁₀H₁₁NO₂
CAS Number	154-02-9
Chemical Information	HMDB01855
Biochemical Taxonomy	Indoles and Indole Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.0009 +/- 0.0003 umol/L Cerebrospinal Fluid (CSF): 0.004 +/- 0.22 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Leukemia Neurological disorders (2 - 18 years old) schizophrenic patients
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Leukemia): 0.12 +/- 0.09 uM Cerebrospinal Fluid (CSF) (Neurological disorders (2 - 18 years old)): 0.009 +/- 0.01 uM Cerebrospinal Fluid (CSF) (schizophrenic patients): 0.11 +/- 0.013 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
5-Hydroxytryptophol is a relatively minor metabolite of serotonin that is excreted primarily as the glucuronide conjugate in human urine. 5-Hydroxytryptophol becomes more important quantitatively during alcohol intoxication, when a shift in the metabolism of serotonin occurs from 5-hydroxyindole acetic acid toward increased (15-fold higher) formation of 5-hydroxytryptophol due to the inhibition of aldehyde dehydrogenase by ethanol-derived acetaldehyde. Urinary excretion of 5-hydroxytryptophol has also been shown to be markedly increased for several hours following intake of foods rich in serotonin, such as bananas. Wide interspecies variation has been reported in the metabolism serotonin to 5-hydroxytryptophol; 5-Hydroxytryptophol makes up 35% of the excreted serotonin metabolites in the rat on average and 10 to 20% in several other species. Human UDP-glucuronosyltransferase 1A6 (UGT1A6) plays a predominant role in the glucuronidation of 5-hydroxytryptophol by human liver microsomes. (PMID 15258112)