5-Hydroxyindoleacetic acid

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5-Hydroxyindoleacetic acid
2D structure for 5-Hydroxyindoleacetic acid
Chemical Name	2-(5-hydroxy-1H-indol-3-yl)acetic acid
Chemical Formula	C₁₀H₉NO₃
CAS Number	54-16-0
Chemical Information	HMDB00763
Biochemical Taxonomy	Indoles and Indole Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Central Nervous System Hippocampus Hypothalamus Liver Nerves Platelet Spinal Cord Spleen Testes Brain
Normal Biofluid Concentrations	Blood: 0.0516 +/- 0.0068 uM Cerebrospinal Fluid (CSF): 0.0004 +/- 0.00007 uM Cerebrospinal Fluid (CSF): 0.143 +/- 0.045 uM Cerebrospinal Fluid (CSF): 0.61 +/- 0.06 uM Urine: 1.57 +/- 0.38 umol/mmol creatinine Urine: 3.0 (0.48-4.5) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Epilepsy Friedrich's Ataxia Hypothyroidism Major depression Schizophrenia Spastic Ataxia
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Schizophrenia): 0.0449 +/-0.0140 uM Blood (Schizophrenia): 0.0475 +/- 0.0130 uM Cerebrospinal Fluid (CSF) (Epilepsy): 0.33 +/- 0.04 uM Cerebrospinal Fluid (CSF) (Friedrich's Ataxia): 0.1 +/- 0.01 uM Cerebrospinal Fluid (CSF) (Hypothyroidism): 0.0003 +/- 0.00006 uM Cerebrospinal Fluid (CSF) (Major depression): 0.08 +/- 0.08 uM Cerebrospinal Fluid (CSF) (Spastic Ataxia): 0.1 +/- 0.02 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
5-hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors. (NCI)