4-Hydroxybutyric acid

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4-Hydroxybutyric acid
2D structure for 4-Hydroxybutyric acid
Chemical Name	4-hydroxy-butanoic acid
Chemical Formula	C₄H₈O₃
CAS Number	591-81-1
Chemical Information	HMDB00710
Biochemical Taxonomy	Hydroxy Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 48.0 (0.0-96.0) uM Cerebrospinal Fluid (CSF): 0.98 +/- 1.17 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Ssuccinic semialdehyde dehydrogenase deficiency
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Cerebrospinal Fluid (CSF) (Ssuccinic semialdehyde dehydrogenase deficiency): 17 - 594 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
4-hydroxybutyric acid may cause bradycardia and dyskinesias. The precise function of GHB in the body is not clear. It is an immediate precursor to GABA, a neurotransmitter which regulates awakeness, physical activity and sleep. As GABA cannot cross the blood-brain barrier, GHB obtained from food may be used for converting to GABA. GHB protects cells from oxygen starvation, which might explain presence of the compound in vital organs. GHB was also found to have neuroprotective capabilities.