3-Nitrotyrosine

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3-Nitrotyrosine
2D structure for 3-Nitrotyrosine
Chemical Name	(2S)-2-amino-3-(4-hydroxy-3-nitro-phenyl)propanoic acid
Chemical Formula	C₉H₁₀N₂O₅
CAS Number	3604-79-3
Chemical Information	HMDB01904
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF)
Tissue Location	Brain Plaques Epidermis Fibroblasts Muscle Neurons Platelet Spinal Cord Brain
Normal Biofluid Concentrations	Blood: 0.85 +/- 1.98 umol/L Cerebrospinal Fluid (CSF): 3.36 (2.81-3.91) uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Bacterial meningitis Patients with oxidative and nitrosative stress
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Patients with oxidative and nitrosative stress): 0.81+/- 0.45 umol/L Cerebrospinal Fluid (CSF) (Bacterial meningitis): 5.54 (3.99-7.09) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
3-Nitrotyrosine (NTyr) is formed in vivo in tissue or blood proteins after exposure to nitrosating and/or nitrating agents such as tetranitromethane. (PMID 8319651) Reactive nitrogen species such as peroxynitrite can nitrate specific amino acids, whether free or protein bound, and 3-nitrotyrosine is believed to be one marker of this reaction. (PMID 10833032)