3-Methylhistidine

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3-Methylhistidine
2D structure for 3-Methylhistidine
Chemical Name	(2S)-2-amino-3-(3-methylimidazol-4-yl)propanoic acid
Chemical Formula	C₇H₁₁N₃O₂
CAS Number	368-16-1
Chemical Information	HMDB00479
Biochemical Taxonomy	Amino Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Skeletal Muscle Muscle
Normal Biofluid Concentrations	Blood: 2.7 (0.0-5.9) uM Blood: 3.0 (2.7 - 5.9) umol/L Cerebrospinal Fluid (CSF): 3.82 +/- 2.43 uM Urine: 15.1 (3.9-26.3) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Alzheimer's Disease Conventional hemodialysis (CHD) Nocturnal hemodialysis (NHD) Probable Alzheimer's Disease
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Conventional hemodialysis (CHD)): 23.7 +/- 18.6 uM Blood (Nocturnal hemodialysis (NHD)): 13.0 +/-10.4 uM Blood (Probable Alzheimer's Disease): 5.16 +/- 1.27 uM Cerebrospinal Fluid (CSF) (Alzheimer's Disease): 2.48 +/- 1.58 uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
3-Methylhistidine is a product of peptide bond synthesis and methylation of actin and myosin. The measurement of 3-Methylhistidine provides an index of the rate of muscle protein breakdown.