3-Methylhistidine

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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

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3-Methylhistidine
2D structure for 3-Methylhistidine
Chemical Name (2S)-2-amino-3-(3-methylimidazol-4-yl)propanoic acid
Chemical Formula C7H11N3O2
CAS Number 368-16-1
Chemical Information HMDB00479
Biochemical Taxonomy

  • Amino Acids

Functional Taxonomy Not Available
Nutritional Taxonomy Not Available
Metabolic Pathways Not Available
Biofluid Location

  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine

Tissue Location

  • Skeletal Muscle
  • Muscle

Normal Biofluid Concentrations

  • Blood: 2.7 (0.0-5.9) uM
  • Blood: 3.0 (2.7 - 5.9) umol/L
  • Cerebrospinal Fluid (CSF): 3.82 +/- 2.43 uM
  • Urine: 15.1 (3.9-26.3) umol/mmol creatinine

Normal Tissue Concentrations Not Available
Diseases / Conditions Related to Nutrition

  • Alzheimer's Disease
  • Conventional hemodialysis (CHD)
  • Nocturnal hemodialysis (NHD)
  • Probable Alzheimer's Disease

Other (Monogenic Disorders) Not Available
Abnormal Biofluid Concentrations

  • Blood (Conventional hemodialysis (CHD)): 23.7 +/- 18.6 uM
  • Blood (Nocturnal hemodialysis (NHD)): 13.0 +/-10.4 uM
  • Blood (Probable Alzheimer's Disease): 5.16 +/- 1.27 uM
  • Cerebrospinal Fluid (CSF) (Alzheimer's Disease): 2.48 +/- 1.58 uM

Abnormal Tissue Concentrations Not Available
Physiological Processes Not Available
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Contents

Introduction

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3-Methylhistidine is a product of peptide bond synthesis and methylation of actin and myosin. The measurement of 3-Methylhistidine provides an index of the rate of muscle protein breakdown.

Biological Function

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Catabolism

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Diseases / Conditions Related to Nutrition

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  • Alzheimer's Disease
  • Conventional hemodialysis (CHD)
  • Nocturnal hemodialysis (NHD)
  • Probable Alzheimer's Disease

Other (Monogenic) Disorders

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Nutritional Information

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Drivers for biological variation

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Vulnerable groups

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