25,26-dihydroxyvitamin D

From NuGOwiki

The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB

Taxonomy Navigation Box; search by

25,26-dihydroxyvitamin D
2D structure for 25,26-dihydroxyvitamin D
Chemical Name	6-[(4E)-4-[(2E)-2-(5-hydroxy-2-methylidene-cyclohexylidene)ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methyl-heptane-1,2-diol
Chemical Formula	C₂₇H₄₄O₃
CAS Number	29261-12-9
Chemical Information	HMDB01420
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.00168 (0.000480-0.00288) uM Blood: 0.0019 +/- 0.001 uM
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Anephrism High Sun Exposure (1 week)
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Anephrism): 0.00144 (0.000720-0.00216) uM Blood (High Sun Exposure (1 week)): 0.00120 (0.000720-0.00168) uM
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

Authors:
Affiliations:

Introduction

guidelines
25,26-(OH)2D3 is a renal microsomal 25-OH-D3 metabolite, whose plasma concentration increases during vitamin D excess concomitantly with an increase in the concentration of lactone. This observation considered with the related structural features of 25,26-(OH)2D3 and lactone (both are oxidized at (C-26) suggested that 25,26(OH)2D3, a metabolite of unknown function, could be a precursor to lactone. In fact, it has been reported that functionalization of C-26 and subsequent lactone formation occurs exclusively in kidney. However, rigorous examination has unambiguously excluded 25S,26-(OH)2D3, the naturally occurring form as a significant lactone precursor. (PMID: 6286629)