2-Methoxyestradiol

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2-Methoxyestradiol
2D structure for 2-Methoxyestradiol
Chemical Name	2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Chemical Formula	C₁₉H₂₆O₃
CAS Number	362-07-2
Chemical Information	HMDB00405
Biochemical Taxonomy	Steroids and Steroid Derivatives
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Lysine Degradation
Biofluid Location	Blood Urine
Tissue Location	Prostate Adipose Tissue
Normal Biofluid Concentrations	Blood: 0.01 +/- 0.00066 umol/L Urine: 0.004 +/- 0.0009 umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Patients with advanced ovarian cancer
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Patients with advanced ovarian cancer): 0.001 (0.0033-0.021) umol/L
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It is derived from estrogen, although it binds poorly to known estrogen receptors, and belongs to the family of drugs called angiogenesis inhibitors. It has undergone Phase 1 clinical trials against breast cancers. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol. It also acts as a vasodilator.