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The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| 14,15-Dihydroxyeicosatrienoic acid | |
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| Chemical Name | (5E,8E,11E)-14,15-dihydroxyicosa-5,8,11-trienoic acid |
| Chemical Formula | C20H34O4 |
| CAS Number | 79551-81-8 |
| Chemical Information | HMDB02342 |
| Biochemical Taxonomy |
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| Functional Taxonomy | Not Available |
| Nutritional Taxonomy | Not Available |
| Metabolic Pathways | Not Available |
| Biofluid Location | Not Available |
| Tissue Location | Not Available |
| Normal Biofluid Concentrations | Not Available |
| Normal Tissue Concentrations | Not Available |
| Diseases / Conditions Related to Nutrition | Not Available |
| Other (Monogenic Disorders) | Not Available |
| Abnormal Biofluid Concentrations | Not Available |
| Abnormal Tissue Concentrations | Not Available |
| Physiological Processes | Not Available |
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Contents |
Introduction
guidelines
14,15-Dihydroxyeicosatrienoic acid (14,15-DHET) is a metabolite of arachidonic acid metabolism. 14,15-DHET is the main product of 14,15-epoxyeicosatrienoic acid (14,15-EET) metabolism in intact human blood vessels. Epoxyeicosatrienoic acids (EETs) are potent regulators of vascular homeostasis and are bound by cytosolic fatty acid-binding proteins (FABPs); FABPs are potent inhibitors of 14,15-EET conversion to 14,15-DHET. Endothelial cells, but not smooth muscle cells, convert 14,15-EET to 14,15-DHET, and this conversion results in a loss of vasodilator activity. 14,15-DHET is a potent activator of peroxisome proliferator-activated receptor alpha (PPARalpha). (PMID: 6798994, 6792198, 17431031, 15284062, 14529287, 11959628)
Biological Function
Catabolism
Diseases / Conditions Related to Nutrition
Other (Monogenic) Disorders