From NuGOwiki
The NuGOwiki Metabolite Database is a joint initiative of NuGO and HMDB
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| 13S-hydroxyoctadecadienoic acid | |
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| Chemical Name | (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid |
| Chemical Formula | C18H32O3 |
| CAS Number | 5204-88-6 |
| Chemical Information | HMDB04667 |
| Biochemical Taxonomy |
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| Functional Taxonomy | Not Available |
| Nutritional Taxonomy | Not Available |
| Metabolic Pathways | Not Available |
| Biofluid Location |
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| Tissue Location | Not Available |
| Normal Biofluid Concentrations |
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| Normal Tissue Concentrations | Not Available |
| Diseases / Conditions Related to Nutrition |
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| Other (Monogenic Disorders) | Not Available |
| Abnormal Biofluid Concentrations |
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| Abnormal Tissue Concentrations | Not Available |
| Physiological Processes | Not Available |
| Authors: | |
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Contents |
Introduction
guidelines
13-hydroxyoctadecadienoic acid (13-HODE) is synthesized in the body from linoleic acid. 13-HODE prevents cell adhesion to endothelial cells and can inhibit cancer metastasis. 13-HODE synthesis is enhanced by cyclic AMP. Gamma-linolenic acid, a desaturated metabolite of linoleic acid, causes substantial stimulation of 13-HODE synthesis. A fall in gamma-linolenic acid synthesis with age may be related to the age-related fall in 13-HODE formation. (PMID 9561154)
Biological Function
Catabolism
Diseases / Conditions Related to Nutrition
- Patients with autosomal dominant polycystic kidney disease (ADPKD)
Other (Monogenic) Disorders