1-Methyladenosine

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1-Methyladenosine
2D structure for 1-Methyladenosine
Chemical Name	(2R,3R,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-purin-9-yl)oxolane-3,4-diol
Chemical Formula	C₁₁H₁₅N₅O₄
CAS Number	15763-06-1
Chemical Information	HMDB03331
Biochemical Taxonomy	Nucleosides
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Urine
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 0.061 +/- .0.006 uM Blood: 0.10 +/- 0.028 umol/L Urine: 18.0 +/- 1.0 umol/mmol creatinine Urine: 5.96 (0.00-12.0) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Chronic Renal Failure (CRF) Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients with Leukemia Patients with Ovarian and Cervix cancer Uremia patients undergoing hemodialysis after treatment patients undergoing hemodialysis before treatment
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Blood (Chronic Renal Failure (CRF)): 0.22 +/- 0.43 uM Blood (Continuous Ambulatory Peritoneal Dialysis (CAPD)): 0.31 +/- 1.0 uM Blood (Patients with Leukemia): 0.071 (0.049-0.125) umol/L Blood (Patients with Ovarian and Cervix cancer): 0.10 (0.076-0.144) umol/L Blood (patients undergoing hemodialysis after treatment): 0.15 +/- 0.01 uM Blood (patients undergoing hemodialysis before treatment): 0.37 +/- .05 uM Urine (Uremia): 4.7 +/- 1.3 umol/mmol creatinine
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
1-methyladenosine is one of the modified nucleosides, the levels of which are elevated in urine of patients with malignant tumors. Examination of expression of 1-methyladenosine is expected to be useful for the histological diagnosis of intraocular tumors. (PMID 8434538)