(S)-3,4-Dihydroxybutyric acid

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(S)-3,4-Dihydroxybutyric acid
2D structure for (S)-3,4-Dihydroxybutyric acid
Chemical Name	3,4-dihydroxybutanoic acid
Chemical Formula	C₄H₈O₄
CAS Number	51267-44-8
Chemical Information	HMDB00337
Biochemical Taxonomy	Hydroxy Acids
Functional Taxonomy	Not Available
Nutritional Taxonomy	Not Available
Metabolic Pathways	Not Available
Biofluid Location	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Not Available
Normal Biofluid Concentrations	Blood: 1.7 (1.2-2.2) uM Blood: 18.0 (0.0-54.0) uM Cerebrospinal Fluid (CSF): 15.0 +/- 15.0 uM Urine: 10.2 (6.4-16.7) umol/mmol creatinine Urine: 11.9 (8.0-38.4) umol/mmol creatinine Urine: 21.2 (9.3-47.0) umol/mmol creatinine Urine: 23.9 (12.4-31.8) umol/mmol creatinine Urine: 34.85 (12.5 - 57.2) umol/mmol creatinine Urine: 8.3 (4.8-22.4) umol/mmol creatinine
Normal Tissue Concentrations	Not Available
Diseases / Conditions Related to Nutrition	Not Available
Other (Monogenic Disorders)	Not Available
Abnormal Biofluid Concentrations	Not Available
Abnormal Tissue Concentrations	Not Available
Physiological Processes	Not Available

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Introduction

guidelines
3,4-Dihydroxybutyric acid is a normal human urinary metabolite that is excreted in increased concentration in patients with succinic semialdehyde dehydrogenase (SSADH) deficiency. (PMID 12127325) Normal adults excrete 0.37 +/- 0.15 (SD) mmoles of 3,4-dihydroxybutyrate per 24 hr. The compound is also detectable in blood. The renal clearance of this compound is roughly equal that of creatinine.